Electrolytes alterations in plasma and urine after 28 days repeated oral dose toxicity of mercuric chloride in wistar rat.

ABSTRACT

An experiment was conducted to study the electrolytes alteration in experimentally induced mercuric chloride in wistar rat. For this rats were uniformly divided in four different dose group 0.0, 2.0, 4.0, and 8.0 mg/kg body weight ranging from asymptomatic to high dose for 28 consecutive days. In this experiment, blood was collected on 0, 14 and at the end of experiment. In mercuric chloride treated group dose dependent significant increase in plasma glucose, sodium, and chloride and creatinine level. Same parameters studied in urine showed significant increase in excretion of electrolytes and glucose in urine while urine creatinine was decrease. Mercuric chloride produced dose depended electrolytes alteration in wistar rat at given dose.