Coronary artery bypass grafting in a patient with protein S deficiency: Perioperative implications.
Ann Card Anaesth
;
2014 Jul; 17(3): 232-236
Article
Dans Anglais
| IMSEAR
| ID: sea-153677
ABSTRACT
Protein S (PS) along with activated protein C plays an important role in the down-regulation of in vivo thrombin generation. Its defi ciency can cause abnormal and inappropriate clot formation within the circulation necessitating chronic anticoagulation therapy. The risk of developing thrombotic complications is heightened in the perioperative period in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Heparin resistance is very rare in these patients, especially when antithrombin levels are near normal. Management of CPB in this scenario is quite challenging. We report the perioperative management, particularly the CPB management, of a patient with type I PS defi ciency and incidentally detected heparin resistance, who underwent coronary artery bypass grafting with CPB.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Humains
/
Mâle
/
Résistance aux substances
/
Héparine
/
Pontage cardiopulmonaire
/
Pontage aortocoronarien
/
Déficit en protéine S
/
Thrombophilie
/
Soins périopératoires
/
Adulte d'âge moyen
langue:
Anglais
Texte intégral:
Ann Card Anaesth
Année:
2013
Type:
Article
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