New insights in the pathogenesis of type 1 and type 2 lepra reaction.
Indian J Dermatol Venereol Leprol
;
2013 Nov-Dec; 79(6): 739-749
Article
Dans Anglais
| IMSEAR
| ID: sea-154672
ABSTRACT
In the current scenario of leprosy elimination, lepra reactions (LRs) remain a major persistent problem. Type 1 LR (T1LR) and type 2 LR (T2LR) are the major causes of nerve damage and permanent disabilities. The immunopathogenesis of LR have recently become an important fi eld of research, since it may provide the relevant targets for the early detection and control of these episodes. Presently, there are no uniformly acceptable laboratory markers for LR. Genetic and serum markers in human host may predict susceptibility to reactions as well as progression of nerve damage in leprosy. Therefore, a deeper understanding of the molecular mechanisms involved in LR may provide a rational strategy for early diagnosis and prevention of the catastrophic consequences of LR.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Humains
/
Marqueurs biologiques
/
Cytokines
/
Immunité innée
/
Lèpre
/
Animaux
/
Mycobacterium leprae
Type d'étude:
Etude d'étiologie
/
Étude pronostique
/
Étude de dépistage
langue:
Anglais
Texte intégral:
Indian J Dermatol Venereol Leprol
Année:
2013
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS