Regulation of N-Myristoyltransferase by the Calpain and Caspase Systems.
Indian J Biochem Biophys
;
2014 Dec ; 51(6): 506-511
Article
Dans Anglais
| IMSEAR
| ID: sea-156530
ABSTRACT
N-myristoyltransferase (NMT) is an essential eukaryotic enzyme which catalyzes the transfer of the myristoyl group to the terminal glycine residue of a number of proteins including those involved in signal transduction and apoptotic pathways. In higher eukaryotes, two isoforms of NMT have been identified (NMT1 and NMT2) which share about 76% amino acid sequence identity in humans. Protein-protein interactions of NMTs reveal that m-calpain interacts with NMT1 whereas caspase-3 interacts with NMT2. These findings reveal differential interactions of both isoforms of NMT with various signaling molecules. This minireview provides an overview of the regulation of N-myristoyltransferase by calpain and caspase systems.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Humains
/
Acyltransferases
/
Calpain
/
Transduction du signal
/
Régulation de l'expression des gènes codant pour des enzymes
/
Caspases
/
Métabolisme lipidique
/
Animaux
/
Modèles biologiques
Type d'étude:
Étude pronostique
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
2014
Type:
Article
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