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Msx1 Gene Variant - its Association in Isolated Hypodontia: A Case Control Genetic study!!!.
Indian J Hum Genet ; 2013 Oct-Dec ;19 (4): 459-464
Article Dans Anglais | IMSEAR | ID: sea-156614
ABSTRACT

INTRODUCTION:

Non‑syndromic tooth agenesis is a congenital anomaly with significant medical, psychological, and social ramifications. There is sufficient evidence to hypothesize that locus for this condition can be identified by candidate genes. AIM OF THE STUDY The aim of this study was to test whether MSX1 671 T > C gene variant was involved in etiology of non‑syndromic tooth agenesis in Raichur patients. MATERIALS AND

METHODS:

Blood samples were collected with informed consent from 50 subjects having non‑syndromic tooth agenesis and 50 controls. Genomic deoxyribonucleic acid (DNA) was extracted from the blood samples, polymerase chain reaction (PCR) was performed, and restriction fragment length polymorphism (RFLP) was performed for digestion products that were evaluated.

RESULTS:

The results showed positive correlation between MSX1671 T > C gene variant and non‑syndromic tooth agenesis in Raichur patients.

CONCLUSION:

MSX1 671 T > C gene variant may be a good screening marker for non‑syndromic tooth agenesis in Raichur patients.
Sujets)

Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Malformations dentaires / Humains / Loi du khi-deux / Facteur de transcription MSX-1 / Inde / Anodontie Type d'étude: Étude observationnelle / Étude pronostique Pays comme sujet: Asie langue: Anglais Texte intégral: Indian J Hum Genet Année: 2013 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Malformations dentaires / Humains / Loi du khi-deux / Facteur de transcription MSX-1 / Inde / Anodontie Type d'étude: Étude observationnelle / Étude pronostique Pays comme sujet: Asie langue: Anglais Texte intégral: Indian J Hum Genet Année: 2013 Type: Article