Antifungal Activity of Terminalia mantaly on the in vitro Growth of Cryptococcus neoformans.

ABSTRACT

Among the HIV / AIDS infected, individuals contract fungal infections of which many die as a direct consequence of these infections. In this study, the antifungal activity of ten extracts (stem bark) from Terminalia mantaly H. Perrier was evaluated on the in vitro growth of clinical isolate of pathogenic fungi (Cryptococcus neoformans). Agar double dilution method in slope tubes was adopted to determine anticryptococcal activity. All extracts exhibited antifungal activity in dose-response relationship. The residue extracts T4-2 obtained after degreasing the hydro-alcoholic extract T0 (MFC = 24.37μg/Ml; IC50 = 5.87μg/mL) is the most active extract. Moreover, for a given concentration it is said that there are not significant differences between the different tests for each extract (P< 0.05). Therefore, using the hydro-alcoholic solvent (70% ethanol) followed by removal of oil is the best way to obtain an optimally concentrated active ingredient from Terminalia mantaly. The present study justifies the traditional use of this plant for the treatment of fungal infections.