Antidiarrhoeal activity on platycladus orieantalis extract.

ABSTRACT

Platycladus is a distinct genus of evergreen coniferous tree in the cypress family Cupressaceae, containing only one species, Platycladus orientalis, also known as Chinese Arborvitae or Biota. It is a small, slowgrowing tree, to 15-20 m tall and 0.5 m trunk diameterThe different parts of the plant are traditionally used as a diuretic, anticancer, anticonvulsant, stomachic, antipyretic, analgesic and anthelmintic [4,5 ]. The plant has not been explored for its anti diarrhoeal activity so far. The bio active fraction has been prove that it contain three major iridoid glycosides. These iridoids glycoside was subjected to anti diarrhoeal activity against validated experimental models like Castor oil induced diarrhea, gastrointestinal motility tests & PGE2-induced enteropooling. The extract inhibited castor oil induced diarrhoea and PGE2 induced enteropooling in rats; it also reduced gastrointestinal motility after charcoal meal administration. The obtained data demonstrated the excellent anti-diarrhoeal activity of P.Orieantalis and thus have great potential as a source for natural health products.