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Anti-Inflammatory Activity of 3-[(5-Substitued)-1, 3, 4 Oxadiazole-2-Yl) Methyl Amino]-2-Methyl Quinazolin-4(3H)-Ones.
Article de En | IMSEAR | ID: sea-163878
The process of establishing a new drug is exceedingly complexioned involves the talents of people from a variety of disciplines including Pharmaceutical chemistry, biochemistry, physiology, pharmacology, pharmaceutics and medicine. Quinazolinone is a heterocyclic chemical compound. There are two structural isomers, 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. Various novel classes of structurally different quinazolinones have been designed and synthesized depicting potential interventions such as antibacterial, antifungal, antiviral, anticonvulsant, anti-inflammatory, antihistaminic, anticancer CNS depressant, and so on. All the synthesized quinazolinone derivatives were confirmed preliminarily by M.P and TLC and further all the synthesized compounds were screened for anti-inflammatory activity using Phenyl butazone as the standard and carragennin induced paw oedema model used for anti-inflammatory activity.
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Texte intégral: 1 Indice: IMSEAR langue: En Année: 2012 Type: Article
Texte intégral: 1 Indice: IMSEAR langue: En Année: 2012 Type: Article