Anticancer Activity of Oscillatoria Terebriformis Cyanobacteria in Human Lung Cancer Cell Line A549.
Article
Dans Anglais
| IMSEAR
| ID: sea-167811
ABSTRACT
Purpose:
To evaluate the anti-cancer properties of the cyanobacterial extract of Oscillatoria terebriformisMethods:
The extract was tested in Human lung cancer cell lines and examined for its effect on cell viability, nuclear morphology and sub-G1 formation. Cell viability was determined by micro culture tetrazolium technique (MTT), nuclear morphology investigated using 4’-6-diamidino-2-phenylindole (DAPI) staining technique, and apoptosis assay using DNA fragmentation.Results:
The results showed decreasing cell viability in a concentration-dependent manner. Altered cell morphology after treatment with the extract demonstrated that cells experienced apoptosis.Conclusion:
The data demonstrate that Oscillatoria Terebriformis extract induced apoptosis in Human lung cancer A549 cells, and therefore, has a potential as an anti-cancer agent.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
langue:
Anglais
Année:
2014
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS