Spectrophotometric determination of chlorpheniramine maleate and phenylpropanolamine hydrochloride in dosage forms.

ABSTRACT

A rapid and simple method for simultaneous determination of Chlorpheniramine Maleate (CPM) and Phenylpropa-nolamine Hydrochloride (PPM) by first derivative UV spectrophotometry has been developed in combined pharmaceutical dosage forms. The proposed method was successfully applied for the determination of drugs in physical mixture and commercial formulations and results showed good linearity, precision and reproducibility.