Glycobiology of Leishmania donovani.
Article
Dans Anglais
| IMSEAR
| ID: sea-17016
ABSTRACT
Leishmania donovani, the causative organism of visceral leishmaniasis (VL) is one of the deadliest of the entire known Leishmania species. This protozoan parasite displays immense adaptability to survive under extremely harsh conditions. Cell surface glycoconjugates play a pivotal role in parasite virulence and infectivity. This review mainly highlights on the importance of these molecules and their reported roles with special emphasis on L. donovani sialobiology. The recently evolved information reported by our group regarding the identification and characterization of sialoglycans and their possible mode(s) of acquisition as also the detailed identification, characterization of anti-O-acetylated sialic acid (anti-OAcSA) antibodies and their emerging biological roles, notably as molecules that may aid in host defense against the pathogen has been vividly discussed in this review.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Polyosides
/
Leishmania donovani
/
Glycoconjugués
/
Glycoprotéines
/
Membrane cellulaire
/
Chromatographie en phase liquide à haute performance
/
Acide N-acétyl-neuraminique
/
Animaux
/
Microscopie de fluorescence
langue:
Anglais
Année:
2006
Type:
Article
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