Methylmercury neurotoxicity & antioxidant defenses.
Article
Dans Anglais
| IMSEAR
| ID: sea-17124
ABSTRACT
Neurotoxicity induced by methylmercury (MeHg) increases the formation of reactive radicals and accelerates free radical reactions. This review summarizes recent findings in the MeHg-induced formation of free radicals and the role of oxidative stress in its neurotoxicity. Oxidative stress on CNS can produce damage by several interacting mechanisms, including mitochondrial damage with increase in intracellular free Ca(2+), activation and inhibition of enzymes, release of excitatory amino acids, metallothioneins expression, and microtubule disassembly. The nature of antioxidants is discussed and it is suggested that antioxidant enzymes and others antioxidants molecules may protect the central nervous system against neurotoxicity caused by MeHg.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Humains
/
Stress oxydatif
/
Animaux
/
Composés méthylés du mercure
/
Système nerveux
/
Antioxydants
langue:
Anglais
Année:
2008
Type:
Article
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