Clinical and microbiological profile of febrile neutropenia in solid tumors and hematological malignancies at a tertiary cancer care center in South India.
Indian J Cancer
;
2014 Oct-Dec; 51(4): 464-468
Article
Dans Anglais
| IMSEAR
| ID: sea-172466
ABSTRACT
BACKGROUND:
Febrile neutropenia (FN) is a common but serious complication of chemotherapy in patients with solid tumors (ST) and hematological malignancies (HM). The epidemiology of FN keeps changing.OBJECTIVE:
The objective was to study the epidemiology of FN in adult patients with ST and HM at Kidwai Memorial Institute of Oncology, Bangalore – A tertiary cancer care center. MATERIALS ANDMETHODS:
Data of all episodes of FN that occurred during the period July 2011 to December 2011 were collected prospectively and analyzed.RESULTS:
A total of 75 episodes of FN was observed during study period involving 55 patients. Febrile neutropenic episodes were more frequent in HM than in ST (57% vs. 43%). The rate of bloodstream infection was 14.7%. Gram‑negative organisms were the predominant isolates (56.25%). Overall mortality rate was 13.3%. Presence of medical co‑morbidity and positive culture predicted high mortality. Mortality rate did not differ significantly between HM and ST (14% vs. 12.5%; P = 1.0). Gram‑positive bacteremia was associated with greater mortality than Gram‑negative bacteremia (P = 0.02).CONCLUSION:
Empiric antibiotic treatment for FN should be tailored to the locally prevalent pathogens and their susceptibility patterns.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
langue:
Anglais
Texte intégral:
Indian J Cancer
Année:
2014
Type:
Article
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