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Obstacles to successful antiretroviral treatment of HIV-1 infection: problems & perspectives.
Article Dans Anglais | IMSEAR | ID: sea-17261
ABSTRACT
Mutations in human immunodeficiency virus type 1 (HIV-1) are a major impediment to successful highly active antiretroviral therapy (HAART) and the design of anti-HIV vaccines. Although HAART has made long-term suppression of HIV a reality, drug resistance, drug toxicity, drug penetration, adherence to therapy, low levels of continued viral replication in cellular reservoirs and augmentation of host immune responses are some of the most important challenges that remain to be sorted out. Continuing viral replication in the face of HAART leads to the accumulation of drug resistance mutations, increase in viral loads and eventual disease progression. Patients who fail therapy have minimal options for their clinical management. Therefore, a clear understanding of the pathogenesis of drug-resistant HIV-1, and all of the issues that influence the success of HAART is urgently needed. In the present article, we discuss various obstacles to HIV therapy, and provide perspectives relating to these issues that are critical in determining the success or failure of HAART.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Inhibiteurs de protéases / Humains / Infections à VIH / Doigts de zinc / VIH-1 (Virus de l'Immunodéficience Humaine de type 1) / Inhibiteurs de protéase du VIH / Évolution de la maladie / Inhibiteurs de la transcriptase inverse / Intégrase du VIH / Agents antiVIH langue: Anglais Année: 2004 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Inhibiteurs de protéases / Humains / Infections à VIH / Doigts de zinc / VIH-1 (Virus de l'Immunodéficience Humaine de type 1) / Inhibiteurs de protéase du VIH / Évolution de la maladie / Inhibiteurs de la transcriptase inverse / Intégrase du VIH / Agents antiVIH langue: Anglais Année: 2004 Type: Article