Excitatory aminoacid neurotransmitters in schizophrenia.
Bangladesh Med Res Counc Bull
;
2005 Apr; 31(1): 15-20
Article
Dans Anglais
| IMSEAR
| ID: sea-178
ABSTRACT
The study presents for the first time the blood level of glutamate and aspartate in schizophrenic patients and in normal subjects in Bangladeshi population. The serum level of glutamate and aspartate were measured in thirty newly diagnosed schizophrenic patients and the same number of subjects matching age was taken from non-schizophrenic control. The age group of the patient was between 15 and 45 years and the male female ratio was 2.71. Serum concentration of glutamate (598.83 +/- 574.48 nmol/ml) was significantly higher (p < 0.001) in schizophrenic group compared to control (196.16 +/- 171.31 nmol/ ml). The serum asparate concentration was also significantly higher in schizophrenic cases (282.91 +/- 299.94 nmol/ml) as compared to control (33.89 +/- 42.68 nmol/ml, p < 0.001). The correlation coefficient between serum glutamate and asparate was significant (p < 0.001). The increased serum glutamate and asparate levels may be the causative or contributing factor in the pathogenesis and progression of schizophrenia.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Schizophrénie
/
Bangladesh
/
Femelle
/
Humains
/
Mâle
/
Études cas-témoins
/
Adolescent
/
Acide aspartique
/
Acide glutamique
/
Acides aminés excitateurs
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Bangladesh Med Res Counc Bull
Année:
2005
Type:
Article
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