Weight Management Effects of a Mixture of Conjugated Linoleic Acid and L-Carnitine in Diet Induced Obese Rats.
Br J Med Med Res
;
2016; 12(1): 1-8
Article
Dans Anglais
| IMSEAR
| ID: sea-182141
ABSTRACT
Aims:
To examine simultaneous effects of Conjugated Linoleic Acid (CLA) and L-carnitine (LC) on weight gain in diet induced obese rats. StudyDesign:
Experimental study. Place and Duration of Study Department of Nutrition, Faculty of Para-Medical Sciences, Ahvaz Jundishapur University of Medical Sciences (January 2014 to January 2015).Methodology:
Forty male Wistar rats were randomly divided into two groups Normal fat diet (n=8), and High fat diet (HFD) (n=32). After eight weeks, the second group maintained HFD and was subdivided into 4 categories Corn Oil group, 500 mg CLA, 200 mg LC, and 500 mg CLA+ 200 mg LC (all doses per kg body weight), which were administered by oral gavage for four weeks. Body weights were measured and recorded weekly by means of a digital scale. SPSS Version 16 was used for statistical analysis.Results:
At the end of eighth week, a significant difference in weights was observed between HFD (295.43±5.36 gr) and NFD (246.38±6.48 gr) group. After four weeks, LC significantly reduced weight gain by 7.5% (P = .047). Trend of weight gain in CLA and LC + CLA groups were decelerated (24 and 25 gr respectively), but it was statistically insignificant (P = .08, .12 respectively).Conclusion:
Findings of this experimental study showed that a high fat diet led to obesity and combined LC and CLA could decelerate weight gain to some extent. However, it needs further work to validate reliability in human.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
langue:
Anglais
Texte intégral:
Br J Med Med Res
Année:
2016
Type:
Article
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