Effect of Raised Mid-trimester Serum hCG and a-fetoprotein on Pregnancy Outcome.

ABSTRACT

Objective: To study the effect of elevated maternal serum human choriogonadotrophin (MShCG) levels and maternal serum a-fetoprotein (MSAFP) levels measured at 14-24 weeks gestation on pregnancy outcome. Material and methods: A prospective study was conducted in 400 antenatal women with gestational age 14-24 weeks attending OPD and Indoor in Dept. of Obstetrics and Gynecology over a period of 12 months. Maternal serum b-hCG and a-fetoprotein levels were measured by fully automated chemiluminesence method. Result: Elevated mid-trimester MShCG levels and MSAFP level were associated with development of pre-eclampsia. Conclusion: Elevated mid-trimester MShCG and MSAFP level may help in the prediction of pre-eclampsia and hence they can be used as screening tools for prediction of pre-eclampsia.