Serum Inflammatory Markers Of Diabetic Kidney Disease And Their Correlation To Lipid Parameters Among Diabetic Individuals Of Eastern India

ABSTRACT

Background: Diabetes mellitus is the leading cause of chronic renal failure . As the period of diabetes progresses there is simultaneous increase of inflammatory markers like high sensitive C reactive protein (hsCRP) with degree of renal involvement, suggested by albumin creatinine ratio and also dyslipidemia in diabetic patients. Materials & Methods: 120 diabetic individuals aged (30-60) yrs, divided in 3 groups of 40 subjects in each, namely a) newly diagnosed˂5 years b) 5-10 years after diagnosis and c) ≥10 years after diagnosis were recruited as study subjects from a tertiary care hospital in sub Himalayan region. Results: Descriptive studies showing mean values of hsCRP ,ACR & lipid parameters were done in all 3 groups. One-way ANOVAwith post hoc analysis after Bonferroni correction in 3 different groups enunciated a significant and statistical increase (p <.001) of both hsCRP &ACR with duration of diabetes unlike the lipid parameters. hsCRP, ACR, cholesterol & LDLeven illustrated a very significant correlation between each other (p<0.001) , TG to hsCRPwhile HDLshowed no correlation to any parameters. Conclusion: Early detection, monitoring of inflammatory markers hsCRP, ACR & deranged lipid parameters are predictors of diabetic nephropathy that can help in modulating diabetes and its complications.