Skeletal fluorosis with progressive quadriparesis U.M.N. type, non compressive myelopathy, chronic kidney disease and secondary hyperparathyroidism and hypothyroidism – A case report.

ABSTRACT

Endemic fluorosis leads to dental fluorosis, skeletal fluorosis and visceral fluorosis. This case described about the crippling skeletal fluorosis with neurological manifestations in the form of myelopathy, due to exposure to high fluoride level in water for many years. The complications of fluoride deposition in bones resulted in generalised sclerosis, osteophytosis, with narrowing of inter vertebral disc spaces in vertebral column. In this case the skeletal fluorosis leads to severe spastic quadriparesis. This case had features of visceral fluorosis; the affected organs include thyroid gland with hypothyroidism, parathyroid gland with secondary hyperparathyroidism, pancreas with intra pancreatic calcification and the kidneys with chronic kidney disease.