Serum enzymes in cerebrovascular accident

ABSTRACT

Background: Brain is a rich source of a variety of enzymes and any injury like stroke to brain tissue could similarly result in an increase in activity of these enzymes in cerebrospinal fluid and serum. It was in this context that the present study was done to assess the levels of enzymes like aspartate aminotransferase (AST), creatine kinase (CK) and Isoenzyme of creatine kinase (CK-MB) in serum. Evaluation of enzyme levels in serum has involved keen interest as a simple, economical, reliable and easily available method for the evaluation of severity, course, prognosis, and to some extent in the differential diagnosis of various types of cerebrovascular accidents. Aim: To study the serum enzymes in cerebrovascular accidents. Materials and methods: The present study was done in Fathima Institute of Medical Sciences, Kadapa, by taking 50 of samples and 30 are controls. Creatine Kinase (Total), Creatine Kinase-MB, Aspartate Transaminase, lipid profile, Fasting Blood Sugar were estimated in patients and control group also. Results: The biochemical parameters studied were fasting blood glucose, total cholesterol, triglycerides, LDL, VLDL, HDL, SGOT, CPK and CPK-MB. Serum CPK was grossly elevated in patients with stroke compared to controls which is statistically significant (P Value < 0.001). Conclusion: In the present study, all the parameters were elevated, for better understanding of serum enzymes in cerebrovascular accidents further investigations are needed