Epidemiology and receptor status distribution in a cohort of carcinoma breast patients presenting in our institution

ABSTRACT

Background: Carcinoma Breast is the most common cancer among females after cervical cancer. An estimated 1 million cases of breast carcinoma have been diagnosed worldwide and it is the leading cause of cancer death among women of age 20-59 years. Aim: The aim of the study is to understand the epidemiological factors and prevalence of different receptor status in cases of Ca breast from the South Indian Population to Govt. Stanley Medical College. Materials and methods: The materials for our retrospective study were collected from the medical records department of Govt. Stanley Medical College (GSMC). All cases of Ca breasts who attended GSMC for admission, treatment, investigations of breast cancer from July 2015 to August 2016 were included in the study. All patients were triple assessed and ER, PR, Her2Neu status were assessed by IHC staining. The study population was grouped based on parameters such as age groups, parity, family history of breast cancer, menopausal status, TNM staging, grade and histological type. Results: In our Study most common age group affected by Ca breast is 41-60 years (57%). 39% of Ca breast cases are premenopausal women. Most common Grade was grade II (41.8%). Most common Histological type was Intra ductal carcinoma about 94.5%. Stage III is common (50.3%). Metastasis was more common in age group > 60years (23%). On comparing stage and grade of tumor 62.8% cases of Stage III were Grade II. Triple Negative cancer is the most common receptor status (25.5%). 57% of triple positive and 57.5% of triple negative cases were in the premenopausal age group. Stage II is the most common presentation in triple positive disease (76.9%). Stage IV is more common in Triple negative patients. K. Muthu Raj MS, S. Mathan Sankar. Epidemiology and receptor status distribution in a cohort of carcinoma breast patients presenting in our institution. IAIM, 2016; 3(12) 75-83. Page 76 Conclusion: In conclusion, our study shows there is an increasing trend of Ca breast in South Indian population among younger and middle age group with Triple Negative Receptors is being most common associated with poor prognostic factors. Hormone receptor status and grading evaluation is needed for targeted therapy