Antioxidant Status in Blood of Patients with Elevated C - reactive protein in Acute Myocardial Infarction

ABSTRACT

Background: C-reactive protein (CRP) is well known as a marker of inflammation associated with cardiovascular diseases (CVD). Methods: The study group included was patients whose CRP level was above 7 mg/L diagnosed with acute myocardial infarction as case and normal healthy donors were taken as control. Results: In our study we have found that antioxidant such as glutathione (GSH) and Glutathione peroxidise (GPx) activity was decreased in blood of patients with acute Myocardial infarction (AMI) with elevated CRP compared to healthy control. We have also found that proxidant molecule such as malondialdehyde (MDA) was increased in AMI in comparison with control. Conclusion: The study concluded that in acute MI associated with inflammation there is imbalance in redox balance