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The anti-inflammatory activity of some sulphonamides in albino rats.
Article Dans Anglais | IMSEAR | ID: sea-18887
ABSTRACT
Clinically equivalent doses of dapsone, sulphasalasine and sulphamethizole in albino rats showed significant (P < 0.05) anti-inflammatory activity in carrageenan and cotton pellet induced inflammation. Their activity was comparable to that of aspirin (200 mg/kg) and was confirmed by granuloma histology. Further, these compounds also showed significant (P < 0.01) analgesic activity which was comparable to that of aspirin. The ulcer index for sulphamethizole was comparable to that of control animals, whereas dapsone and sulphasalazine showed significant ulcerogenicity (P < 0.01). Other sulphonamides like sulphadiazine, sulphanilamide, sulphamoxole and cotrimoxazole did not show significant anti-inflammatory and analgesic activities.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Rats / Sulfasalazine / Sulfaméthizol / Femelle / Mâle / Acide acétylsalicylique / Rat Wistar / Dapsone / Animaux / Anti-inflammatoires langue: Anglais Année: 1996 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Rats / Sulfasalazine / Sulfaméthizol / Femelle / Mâle / Acide acétylsalicylique / Rat Wistar / Dapsone / Animaux / Anti-inflammatoires langue: Anglais Année: 1996 Type: Article