An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement
Article
| IMSEAR
| ID: sea-196187
ABSTRACT
Rearrangements involving interferon regulatory factor 4 (IRF4) gene has been recently described in a subtype of diffuse large B-cell lymphoma (DLBCL). They occur in a typical clinical setting of a pediatric age group, predominantly with tonsillar mass, usually as a low-stage disease and with good response to chemotherapy. Histomorphologically, they show nodular/follicular architecture with diffuse strong immunopositivity for multiple myeloma oncogene 1. Here, the authors describe one such unusual case of large B-cell lymphoma with IRF4 gene rearrangement in a young child with the unusual location of inguinal region and detailed pathological (histological, immunohistochemical, and molecular) findings.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Année:
2018
Type:
Article
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