A Study Of The Oxidative Stress And Antioxidant Status In Diabetic Subjects Who Are On Treatment With Metformin

ABSTRACT

Background:Oxidative stress plays an important role in the pathogenesis of DM and its complications. However, antioxidant status and its contribution to type 2 DM are less explored in South Indian population. Metformin, is a bi-guanide anti hyperglycemic agent used for the management of type 2 diabetes. Aim:To study the alteration in oxi-dant and antioxidant status in type 2 diabetic subjects on treatment with Metformin and to evaluate the effect of met-formin in improving the total antioxidant status. Methodology:All subjects were T2DM patients, on metformin mon-otherapy(500mg,bd)andweregroupedintoGroup1andGroup2basedontheirHbA1cvalueswithresponsetometformin. Baseline parameters (B.P, Waist Hip ratio, BMI, family history), glycemic status, lipid profile, Total anti-oxidant capacity (TAC), Malondialdehyde (MDA) and serum Metformin levels were assayed. Results:Fasting insulin (?Iu/ml), TAC (?M), MDA (nmol/ml), Metformin (?g/ml) values in group 1 and group II are 22.38 ± 2.7, 14 ± 3.9, 268.71± 23.12, 355.75 ± 26.32, 3.37 ± 0.21, 1.68 ± 0.05, 0.17 ± 0.01, 0.08 ± 0.005 respectively. Oxidative stress was higher with reduced antioxidant status in Group I compared to Group II subjects. Conclusion:It may be concluded that total antioxidant status is lower in type 2 diabetic subjects of Group 1 category compared to diabetic subjects in the Group 2 and it may be related to the beneficial effects of the biguanide, Metformin.