Analgesic activity of gold preparations used in Ayurveda & Unani-Tibb.
Article
Dans Anglais
| IMSEAR
| ID: sea-20092
ABSTRACT
Calcined gold preparations, Ayurvedic Swarna Bhasma (SB) and Unani Kushta Tila Kalan (KTK) were investigated for analgesic effects in rats and mice using four types of noxious stimuli. Auranofin (AN) used in modern medicine was also studied for comparisons. The test drugs SB and KTK (25-50 mg/kg, p.o.) and AN (2.5-5.0 mg/kg, p.o.) exhibited analgesic activity against chemical (acetic acid induced writhing), electrical (pododolorimeter), thermal (Eddy's hot plate and analgesiometer) and mechanical (tail clip) test. While the analgesic effects of SB and KTK could be partly blocked by pretreatment with naloxone (1-5 mg/kg, i.p.,--15 min), such antagonism was not discernible with AN at the doses used. Involvement of opioidergic mechanism is suggested for the observed analgesic activity.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Rat Wistar
/
Or
/
Analgésiques
/
Animaux
/
Souris
/
Noxas
langue:
Anglais
Année:
1998
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS