Study on Effect of Atorvastatin on High Sensitivity C-reactive Protein, Pulmonary Function and Quality of Life in Chronic Obstructive Pulmonary Disease

ABSTRACT

Introduction: Statins have been demonstrated to have antiinflammatory and immunomodulatory properties which arecapable of attenuating inflammatory response in sepsis. Theirlipid-lowering capabilities have been well known specifically inpatients at risk of atherosclerotic cardiovascular events.Methodology: The population of this study in 60 cases. Whichwere divided in two groups. In group I cases receivedtreatment for COPD & in group II Who received treatment forCOPD along with 20 mg/day atorvastatin. The duration of studywas over a period of one year. This study was conducted in theDepartment of Pulmonary medicine, Department ofBiochemistry & Department of Pharmacology, PMCH, Patna.Results: In group I we found the ratio of male female was228, while in group II male female was 237.In this study weobserved that stage of severity of COPD in both groups; whichwere seen moderate 27 & 25 in group I & group II respectively.Conclusion: The study concludes that a significant decreasein serum hs-CRP levels in COPD patient with the use of 20mg/day atorvastatin for 12 weeks.