Study the Effect of a Single Dose of Intravenous Magnesium Sulphate on Postoperative Pain after Lower Abdominal Surgery

Background: Uncontrolled post-operative pain may produce arange of detrimental acute and chronic effects. Relief fromsevere pain arising from deep or visceral structures, ashappens in surgical procedures, requires the use of opioids.The aim of this study to assess the degree and duration ofpostoperative pain and requirements of rescue analgesia afterIntravenous use of magnesium sulphate preoperatively in lowerabdominal surgery.Materials & Methods: This is a hospital based randomizeddouble blind interventional analytic study done on 50 patientsadmitted in surgery department for lower abdominal surgery atS.M.S. medical college and attached hospital, Jaipur. Aftertaking informed consent and confirming overnight fasting,patient was taken on the recovery room and baseline vitalslike B.P., pulse rate, respiratory rate recorded. Patients at restwas evaluated by using a 0 – 10 cm. visual analogue score(VAS) or by using a 0 - 4 verbal rating score (VRS) atemergence from anaesthesia and1/2, 1, 2, 4, 6, 12 and 24 hrs.after surgery.Results: There was no significant difference in mean age ofpatients between two groups (P > 0.05). The mean of totaldose of analgesia requested was 87.00+ 27.49 mg in MgSO4group and 240.00 + 30.00 mg in C group. It means that therewas clinically and statistically highly significant (P<.001). Themean duration of analgesia was 189.60+18.70 minutes inMgSO4 group and 24.40 + 5.16 minutes in C group. In ourstudy occurrence of nausea and vomiting were more in Cgroup then the MgSO4 group. But these adverse effects werestatistically insignificant in both the groups and did not requireany supplementary management.Conclusion: We concluded that patients receiving Magnesiumsulphate during preoperative period have better pain relief,more sedated and fewer requirements of rescue analgesics inthe postoperative period, without any major side effects.