Utility of Global Longitudinal Strain in Predicting Obstructive Coronary Artery Disease in Intermediate Risk Patients

ABSTRACT

Introduction: Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality in the world and hasnearing its epidemic proportions. Although CAD mortality rates worldwide have declined over the past four decades, CADremains responsible for about one-third or more of all deaths in individuals overage.Aims and Objectives: The primary objective of the study is to see the correlation between global longitudinal strain assessedby tissue Doppler imaging or two-dimensional (2D) speckle tracking echocardiography and CAD as assessed by coronaryangiography in intermediate-risk patients.Materials and Methods: This was a prospective clinical study, Department of Cardiology, Nizam’s Institute of Medical Sciences,Hyderabad. Patients admitted with symptoms of stable CAD during the period June 12 to November 30, 2017 were studied.Results: Total number of patients with a clinical diagnosis of stable angina at intermediate risk of CAD as per FraminghamRisk Score admitted to the hospital during the study period is 50. Out of 50 patients, five patients refused coronary angiogram.Conclusion: Global longitudinal strain (GLS) assessed by 2D-STE at rest is a predictor of significant CAD. GLS has highsensitivity for early detection of significant CAD in intermediate risk patients. 2D-STE has the potential to improve the value ofchocardiography in the detection of the CAD, identifying high-risk patients.