Central alpha-adrenoceptor influence over the cardiovascular reflexes activated by veratrine.
Article
Dans Anglais
| IMSEAR
| ID: sea-21389
ABSTRACT
Intravenous veratrine induced alterations in cardiovascular parameters in cats were used as a tool for assessing the influence of central alpha-adrenoceptors over reflex adjustments in the heart rate and blood pressure. Blockade of central alpha 2-adrenoceptors with idazoxan or yohimbine, inhibited, while their activation by clonidine, as also blockade of alpha 1-adrenoceptors, with prazosin, potentiated the veratrine induced bradycardia. The hypotensive effect was relatively unaltered by these treatments. Low doses of clonidine potentiated the veratrine-induced bradycardia. It appears that alpha 2-adrenoceptor mechanisms exert greater control over the reflex regulation of heart rate than over reflex control of blood pressure.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Pression sanguine
/
Vératrine
/
Chats
/
Récepteurs alpha-adrénergiques
/
Rythme cardiaque
/
Animaux
langue:
Anglais
Année:
1989
Type:
Article
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