Dynamics of sequestering the limiting p300/CBP, viral cis-regulatory elements, and disease
J Biosci
;
2020 Jun; : 1-5
Article
| IMSEAR
| ID: sea-214281
ABSTRACT
Many studies showed that the p300/CBP coactivator is limiting. Here we review three studies that showed howtranscription complexes formed on viral cis-regulator elements compete with cellular transcription complexesby sequestrating the p300/CBP coactivator. According to the microcompetition model, this sequestering cancause disease. We use the microcompetition model to explain how a specific type of sequestering, caused by alatent virus that has an active cis-regulatory element in its promoter/enhancer that binds the transcriptioncomplex p300/CBPGABP can cause diseases such as cancer, atherosclerosis, diabetes, and certain autoimmune diseases.
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Disponible
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IMSEAR (Asie du Sud-Est)
Texte intégral:
J Biosci
Année:
2020
Type:
Article
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