Measles virus phosphoprotein inhibits apoptosis and enhances clonogenic and migratory properties in HeLa cells
J Biosci
;
2019 Mar; 44(1): 1-9
Article
| IMSEAR
| ID: sea-214435
ABSTRACT
Measles virus is the causative agent of measles, a major cause of child mortality in developing countries. Two majorproteins, coded by the viral genome, are nucleocapsid protein (N) and phosphoprotein (P). The N protein protects the viralgenomic RNA and forms ribonucleoprotein complex (RNP) together with P protein. MeV-P protein recruits the largeprotein (L), i.e. viral RNA-depended RNA polymerase (RdRp), to ensure viral replication in host cell. Apoptogenicproperties of N protein of Edmonston vaccine strain have been established in our lab previously. We investigated the role ofMeV-P protein of Edmonston vaccine strain as modulator of apoptosis in cervical cancer cell line (HeLa) and found thatMeV-P protein is anti-apoptotic and enhances cell proliferation. Measles virus is considered to be innately oncotropic virus.However, the anti-apoptotic property of MeV-P protein raises important concerns while adopting this virus as an anti-cancertherapeutic tool.
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Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Texte intégral:
J Biosci
Année:
2019
Type:
Article
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