Real-world observational study of escitalopram for newly diagnosed versus relapsed patients with major depressive disorder in India
Article
| IMSEAR
| ID: sea-217698
ABSTRACT
Background:
Depression is common yet under-reported disorder in the real-world setting. Although antidepressants have demonstrated superiority over placebo in clinical trials, many patients elicit a suboptimal response or relapse. Moreover, real-world data in the Indian population are limited. Aim andObjective:
This study aims to assess and compare the efficacy and safety of escitalopram in patients with newly diagnosed depression (NDD) versus relapse in India. Materials andMethods:
This is an ongoing real-world observational study of escitalopram in patients with NDD or relapse in India. Primary endpoint was change in mean Hamilton Depression Rating Scale (HAM-D 17) scores from baseline to week 8. Secondary endpoints included assessment of response/remission rates, Clinical Global Impression (CGI) scores, quality of life, suicidal tendency, and safety.Results:
Data for the first 50 patients demonstrated a significant reduction in HAM-D 17 scores at week 8 (P < 0.001); patients with NDD (n = 38) elicited significantly higher improvement compared with relapsed patients (n = 12) (P < 0.001). Although patients with NDD had significantly poorer CGI (P < 0.001) and quality of life (anxiety/depression subscale) (P < 0.05) scores at baseline, an improvement was observed in both scales with no significant difference between the groups at week 8. Suicidal tendency reduced from 83.3% to 0%. No new safety concerns were observed in the study.Conclusion:
Escitalopram demonstrated efficacy and was well tolerated in both, NDD and relapsed patients in the real-world setting in India, with better results achieved by NDD patients. However, more studies are required to confirm the difference across the groups.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Année:
2022
Type:
Article
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