HLA antigen profile in pulmonary tuberculosis patients & their spouses.
Article
Dans Anglais
| IMSEAR
| ID: sea-22193
ABSTRACT
HLA-A, -B, -DR and -DQ antigen profile was studied in pulmonary tuberculosis patients (n = 209) and their spouses (family contacts; n = 50) and healthy volunteers (n = 72). An increased frequency of HLA-A-10, B7, B15, DR2 and DQ1 was seen in the pulmonary-TB (PTB) patients when compared to the total control subjects (n = 122). However, a significant increase was seen only with HLA-DR2 (P < 0.001; Pc < 0.01; Relative Risk 2.3) and -DQ1 (P < 0.005; Pc < 0.015; Relative Risk 2.8). Among the spouses and the corresponding patients, a similar increase of HLA-DR2 was seen. A decreased frequency of HLA-A19, B8, B17, B35, DR5 and DR6 were seen in PTB as compared to control groups. The present study suggested that HLA-DR2 and DQ1 genes/gene products may be associated with the susceptibility to tuberculosis either alone or in combination with other HLA or non-HLA genes.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Tuberculose pulmonaire
/
Femelle
/
Humains
/
Mâle
/
Antigènes HLA-DQ
/
Antigène HLA-DR2
/
Conjoints
/
Adulte
/
Antigènes HLA
Type d'étude:
Etude d'étiologie
langue:
Anglais
Année:
1998
Type:
Article
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