Hirschsprung’s disease and associated syndrome and malformation: A case series of four cases

ABSTRACT

Hirschsprung’s disease is a genetic disorder characterized by the absence of ganglion cells in different lengths of the intestine. It is one of the common causes of intestinal obstruction in neonates. We treated four cases of syndromic Hirschsprung’s disease from January 2017 to January 2020 in a Tertiary care hospital. The biopsy specimens from spastic segment and colostomy or ileostomy sites were sent for evaluation of ganglion cells. Two different syndromes and one associated malformation and neoplasm were detected in patients of Hirschsprung’s disease during this 3-year case study.