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Bullous pemphigoid in India: Review of cases registered in an autoimmune bullous disease clinic
Article | IMSEAR | ID: sea-223158
ABSTRACT

Background:

Information on bullous pemphigoid in an Indian context is scarce.

Aim:

To report clinico-demographic profile, associated comorbidities and prescription pattern of bullous pemphigoid patients in India.

Methods:

This was a retrospective study, where past records of all bullous pemphigoid patients diagnosed and treated between November 2013 and October 2019 were accessed and analysed. Patients having a compatible clinical presentation with either histopathological and/or direct immunofluorescence evidence of bullous pemphigoid were included.

Results:

There were 96 bullous pemphigoid patients, with a male female ratio of 1.61. The mean age at diagnosis was 62.5 ± 2.2 years, with mean duration of illness 27.5 ± 4.5 months before presentation. Comorbidities were present in 80 (83%) patients, with type 2 diabetes mellitus (38.5%), hypertension (36.4%) and neurological illness (16.7%) being the commonest ones. Clinically, blisters were the predominant presentation in 81 (84.4%) patients. The majority (87.5%) of patients showed a predominant eosinophilic infiltrate on histopathology. Direct immunofluorescence revealed immunoglobulin G deposits with complement C3 in 77 (80.2%) cases. The majority of patients (77.1%) were treated with oral prednisolone, either alone (11.5%) or in combination (65.6%) with other topical and systemic agents. Topical steroids were used in 29.1%, azathioprine in 28%, dapsone in 16.7% and omalizumab in 6.2% of patients.

Limitations:

The study is retrospective. Immunofluorescence on salt split skin, direct immunofluorescence serration pattern analysis, and immunoblotting were not performed. Hence, there is a possibility that a few included cases were suffering from other subepidermal autoimmune bullous diseases like epidermolysis bullosa acquisita or anti-p200 pemphigoid.

Conclusion:

Bullous pemphigoid patients in this study had a younger age of onset and showed male preponderance. Comorbidities like type 2 diabetes, hypertension and neurological disorders were freq

Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Année: 2023 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Année: 2023 Type: Article