Assessment of Causality in Hospitalized Children With AminoglycosideRelated Nephrotoxicity
Indian Pediatr
;
2022 Mar; 59(3): 226-229
Article
| IMSEAR
| ID: sea-225309
ABSTRACT
Objectives:
To evaluate the incidence of aminoglycoside-related nephrotoxicity and ascertain drug causality and its risk factors.Methods:
This prospective study was conducted from January, 2019 to January, 2021, and recruited 110 consecutively admitted children aged 1 month to 12 years, receiving aminoglycosides for ?4 days. Drug causality was assessed using Liverpool adverse drug reaction causality assessment tool.Results:
42 (38.2%) children developed acute kidney injury (AKI), with 71 (64.5%) having composite nephrotoxicity (AKI and/or tubular-dysfunction). Only 17 (15.5%) had AKI definitively attributable to aminoglycosides. Hypotension [OR 0.016 (95% CI 0.01-0.71), P=0.03], PRISM-III score 20-29% [OR 55.48 (95% CI 3.66-840.53), P=0.004] and post-surgery patients [OR 3.2 (95% CI 1.01-10.1), P=0.047] were independent predictors of AKI.Conclusions:
Only a small proportion of children receiving aminoglycosides had AKI definitively attributable to the drug.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Texte intégral:
Indian Pediatr
Année:
2022
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS