Assessment of abnormal celiac serological marker in newly diagnosed cases of DM-I without gastrointestinal tract symptoms

Objective: To assess the abnormal celiac serological marker (anti-tissue transglutaminase IgA) in newly diagnosed cases of DM-I without gastrointestinal tract symptoms. Material and methods: This cross sectional study was conducted at Department of Pediatric Medicine, Bahawal Victoria Hospital, Bahawalpur. Total 87 newly diagnosed of DM-I without GIT symptoms either male or female having age from 6-16 years were selected for this study. Results: Mean age of the children was 11.43 ± 3.78 years. Out of 70 patients, total 17 (20%) patients found with abnormal celiac serological markers. Total 12 (13.79%) patients were found with family history of DM and abnormal celiac serological marker was seen in 5 (41.67%) patients. Total 75 (86.21%) patients found without family history of DM and abnormal celiac serological marker was seen in 12 (16%) patients. Association between abnormal celiac serological marker and family history of DM was statistically significant with p value 0.05. Conclusion: Results of this study showed a high percentage of abnormal celiac serological marker. Insignificant association of abnormal celiac serological marker with age and gender was detected. But significantly associated with family history of diabetes mellitus.