Hepatoprotective activity of silymarin against hepatic damage in Mastomys natalensis infected with Plasmodium berghei.
Article
Dans Anglais
| IMSEAR
| ID: sea-23926
ABSTRACT
Silymarin, a flavolignan from the seeds of Silybum marianum, showed significant hepatoprotective activity in P. berghei-induced hepatic damage in M. natalensis, as assessed by changes in several serum and liver biochemical parameters. Changes in lipoprotein-X, GOT, GPT, alkaline phosphatase and bilirubin were found to be protected by silymarin at different doses. Maximum activity was observed at a dose of 5 mg/kg bw, po. Silymarin had no effect on parasitaemia.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Plasmodium berghei
/
Silymarine
/
Flavonoïdes
/
Mâle
/
Modèles animaux de maladie humaine
/
Relation dose-effet des médicaments
/
Hépatite animale
/
Tests de la fonction hépatique
/
Animaux
/
Paludisme
langue:
Anglais
Année:
1989
Type:
Article
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