Synthesis, physico-chemical and biological properties of some alkali metals and quaternary alkylammonium salts of polyene antibiotics: amphotericin B, nystatin and aureofungin.
Hindustan Antibiot Bull
;
1994 Feb-May; 36(1-2): 34-8
Article
Dans Anglais
| IMSEAR
| ID: sea-2430
ABSTRACT
Polyene antibiotics are known for their remarkable antifungal properties. The alkali metal and quaternary alkylammonium salts of amphotericin B, nystatin and aureofungin have been prepared by ion-exchange method. The physico-chemical and biological properties of these salts have been studied with a view to evaluate their therapeutic advantages over the parent compounds. While the majority of the salts reported herein showed more water solubility; triethylammonium salts, unlike the other alkali metal salts, possessed marginally improved or similar bioactivity in comparison to their parent antibiotic having reduced toxicity.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Polyènes
/
Candida albicans
/
Chimie physique
/
Amphotéricine B
/
Nystatine
/
Phénomènes chimiques
/
Composés d'ammonium quaternaire
/
Métaux
/
Antifongiques
langue:
Anglais
Texte intégral:
Hindustan Antibiot Bull
Année:
1994
Type:
Article
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