Effect of trisodium pentetat on the distribution of cadmium in some body organs & on hepatic metallothionein in rats.
Article
Dans Anglais
| IMSEAR
| ID: sea-24369
ABSTRACT
The pre- and post-treatment with calcium trisodium diethylene-triaminepentaacetic acid (CaNa3DTPA) was investigated for their efficacy to mobilize cadmium (Cd) from various tissues and hepatic metallothionein (MT) in Cd-exposed rats. Pretreatment with CaNa3 DTPA significantly reduced the hepatic and renal Cd absorption while, post Cd treatment with CaNa3 DTPA was effective in reducing renal and brain Cd. Pretreatment with CaNa3DTPA significantly increased the Cd induced hepatic metallothionein (MT) level, MT-bound Cd, Zn and Cu contents while, post treatment with CaNa3DTPA reduced the hepatic MT, MT-bound Cd compared to Cd alone treated rats.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Femelle
/
Cadmium
/
Intoxication au cadmium
/
Distribution tissulaire
/
Acide pentétique
/
Foie
/
Animaux
/
Métallothionéine
langue:
Anglais
Année:
1989
Type:
Article
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