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Effect of chlorpromazine and gossypol on Ca(2+)-ATPase activity in the microsomal membranes of rat testes.
Indian J Biochem Biophys ; 1991 Apr; 28(2): 136-9
Article Dans Anglais | IMSEAR | ID: sea-26495
ABSTRACT
The microsomal membranes isolated from rat testes have been found to contain a Mg(2+)-dependent and a Mg(2+)-independent Ca(2+)-ATPase. The enzyme activities were inhibited by two contraceptive drugs--gossypol and chlorpromazine. The inhibition by the former was affected by the presence of ligand(s) and not the substrate in the incubation medium, whereas ligand(s)/substrate did not affect the inhibition by chlorpromazine. This may be explained from the fact that the binding of chlorpromazine and ligand(s)/substrate to the enzyme are independent of each other whereas in case of gossypol the ligand(s) compete with the drug at the binding site of the enzyme.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Rats / Testicule / Mâle / Gossypol / Cinétique / Chlorpromazine / Ca(2/) Mg(2/)-ATPase / Calcium-Transporting ATPases / Membranes intracellulaires / Animaux langue: Anglais Texte intégral: Indian J Biochem Biophys Année: 1991 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Rats / Testicule / Mâle / Gossypol / Cinétique / Chlorpromazine / Ca(2/) Mg(2/)-ATPase / Calcium-Transporting ATPases / Membranes intracellulaires / Animaux langue: Anglais Texte intégral: Indian J Biochem Biophys Année: 1991 Type: Article