Increase in alpha-glycerophosphate dehydrogenase and other oxidoreductase activities of hepatic mitochondria on administration of vanadate to the rat.
Indian J Biochem Biophys
;
1989 Aug; 26(4): 227-33
Article
Dans Anglais
| IMSEAR
| ID: sea-26597
ABSTRACT
Liver mitochondria isolated from vanadate-administered rats showed increased (20-25%) rates of oxidation of both NAD(+)-linked substrates and succinate. Respiratory control index and ADP/O were unaffected by the treatment. Dormant and uncoupler-stimulated ATPase activity also was not affected by vanadate administration. Membrane-bound, electron-transport-linked dehydrogenase activities (both NAD(+)- and succinate-dependent) increased by 15-20% on vanadate treatment. Mitochondrial alpha-glycerophosphate dehydrogenase activity increased by 50% on vanadate administration. The above effects of vanadate on oxidoreductase activities could be prevented by the prior administration of antagonists to alpha-adrenergic receptors. Substrate-dependent H2O2 generation by mitochondria also showed an increase on vanadate administration.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Phosphorylation oxydative
/
Oxidoreductases
/
Rats
/
Lignées consanguines de rats
/
Mâle
/
Mitochondries du foie
/
Vanadates
/
Peroxyde d'hydrogène
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
1989
Type:
Article
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