A new fragmentation rearrangement of the N-terminal protected amino acids using ESI-MS/MS.
Indian J Biochem Biophys
;
2006 Dec; 43(6): 372-6
Article
Dans Anglais
| IMSEAR
| ID: sea-26618
ABSTRACT
A novel fragmentation rearrangement reaction with a carboxyl oxygen negative charge migration was observed in the N-terminal protected amino acids including Fmoc-protected phosphoserine. phosphothroenine, and phosphotyrosine and their analogues using the electrospray ionization tandem mass spectrometry (ESI-MS/MS). The possible mechanism of a five-membered ring transition state was proposed and supported by the further experiments. It was found that the tendency of the rearrangement was determined by the blocking status of its C-terminal and the reaction was proved to be independent of the N-terminal and side-chain protecting groups of the amino acids.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Fragments peptidiques
/
Phosphopeptides
/
Spectrométrie de masse ESI
/
Fluorènes
/
Acides aminés
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
2006
Type:
Article
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