Further characterization of negative regulatory element involved in the hormonal regulation of GlcNAc-1-P transferase gene in mouse mammary gland.
Indian J Biochem Biophys
;
1997 Feb-Apr; 34(1-2): 110-7
Article
Dans Anglais
| IMSEAR
| ID: sea-26880
ABSTRACT
The gene encoding UDP-GlcNAcdolichol phosphate N-acetylglucosamine-1-phosphate transferase (GPT), the enzyme that initiates the pathway for the biosynthesis of asparagine-linked glycoproteins, is ubiquitously expressed in eukaryotic cells. However, its expression in the mammary gland is developmentally and hormonally regulated; transcription of the mouse mammary GPT gene is stimulated by the lactogenic hormones, insulin, glucocorticoid, and prolactin. Earlier, we demonstrated that a distal negative regulatory element in mouse GPT (mGPT) promoter plays an important role in developmental and hormonal control of mGPT gene expression in mammary gland (Ma J, Saito H, Oka T and Vijay IK (1996) J Biol Chem, in press). In this report, a tissue distribution of the repressor that binds the negative regulatory element was examined; a comparison of the negative regulatory element to other consensus sequences for known transcription factors is discussed.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Oligodésoxyribonucléotides
/
Protéines de répression
/
Femelle
/
Séquence nucléotidique
/
Régulation de l'expression des gènes codant pour des enzymes
/
Gènes régulateurs
/
Régions promotrices (génétique)
/
Transferases (other substituted phosphate groups)
/
Animaux
/
Glandes mammaires animales
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
1997
Type:
Article
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