Polyene antibiotics in the membrane environment.
Indian J Biochem Biophys
;
1991 Aug; 28(4): 227-32
Article
Dans Anglais
| IMSEAR
| ID: sea-26901
ABSTRACT
The cytotoxic activity of the polyene antibiotics mainly depends on the appearance of the drug species which arises from drug-sterol complexation. The unsaturation and intact macrolide ring of the polyenes are the requirements for the biological activity. All the polyene antibiotics can form the complex with the sterol having 3 beta-OH group, and planar ring and a hydrophobic side chain. Aromatic polyene antibiotics with positively charged head group have been considered as most potential antifungal agents.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Stérols
/
Relation structure-activité
/
Vecteurs de médicaments
/
Amphotéricine B
/
Filipine
/
Liposomes
/
Animaux
/
Lipides membranaires
/
Antibactériens
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
1991
Type:
Article
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