Effect of metal ions on binding of bilirubin to erythrocyte membranes.
Indian J Biochem Biophys
;
2001 Aug; 38(4): 230-4
Article
Dans Anglais
| IMSEAR
| ID: sea-27182
ABSTRACT
Binding of bilirubin to different erythrocyte membranes, namely, human, buffalo, sheep and goat, pre-incubated with different concentrations of metal ions was studied. The results showed that among the different metal ions used, Ca2+ had the highest potential in increasing the amount of bound bilirubin followed by Sr2+ and Mg2+, whereas Ba2+ had the lowest potential. Treatment of these membranes with Ca2+ led to an increase in the amount of bound bilirubin in all membranes. However, human erythrocyte membranes pretreated with Ca2+, bound the highest amount of bilirubin compared to other erythrocyte membranes. Increase in bilirubin binding upon Ca2+-treatment can be ascribed to shielding effect, redistribution of phospholipids as well as increase in surface hydrophobicity induced by Ca2+.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Liaison aux protéines
/
Température
/
Bilirubine
/
Humains
/
Bovins
/
Capra
/
Ovis
/
Cations divalents
/
Membrane érythrocytaire
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
2001
Type:
Article
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