Molecular characteristics of soluble arthritic collagens.
Indian J Biochem Biophys
;
1990 Feb; 27(1): 33-8
Article
Dans Anglais
| IMSEAR
| ID: sea-27318
ABSTRACT
The molecular characteristics of acid-soluble collagen prepared from animals rendered adjuvant arthritis and matched controls have been thoroughly investigated. The arthritic process was induced in rats by the injection of paraffin oil containing the suspension of heat-killed Mycobacterium tuberculosis at the dorsum of the tail root. In comparison to the normal, the arthritic collagens consistently demonstrated increased solubility of reconstituted fibrils and marked decrease in intrinsic viscosity. Digestion of arthritic collagens with various proteolytic enzymes showed an increased susceptibility over normal collagens. Electrophoresis on SDS-polyacrylamide gels revealed a marked decrease in the concentration of beta-components of arthritic collagens and appreciable increase in the ratio of alpha to beta subunit component. The data clearly indicate that the arthritic collagens are very poor in polymerization due to the impairment of intra and inter-molecular interactions. These changes could explain in part, the altered response of the connective tissues to inflammation and arthritis.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Arthrite
/
Arthrite expérimentale
/
Rats
/
Lignées consanguines de rats
/
Mâle
/
Chimie physique
/
Collagène
/
Phénomènes chimiques
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
1990
Type:
Article
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