Atherogenic diet alters folate enzymes in mice: implications of folate deficient homocysteinemia.
Indian J Biochem Biophys
;
1998 Oct; 35(5): 303-7
Article
Dans Anglais
| IMSEAR
| ID: sea-27350
ABSTRACT
The two key enzymes, methylenetetrahydrofolate reductase and methionine synthase involved in methionine synthesis from homocysteine were studied in atherogenic diet fed mice. Methylenetetrahydrofolate reductase activity was elevated while methionine synthase was impaired in atherogenic diet fed group. Impaired methionine synthase activity would adversely affect the methionine synthesis from homocysteine, resulting in a rise in the homocysteine levels, which are atherogenic. This is reflected by the increased levels of very low density and low density lipoprotein cholesterol values and a higher ratio for total cholesterol to high density lipoprotein cholesterol.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
5-Methyltetrahydrofolate-homocysteine s-methyltransferase
/
Mâle
/
Methylenetetrahydrofolate reductase (NADPH2)
/
Régime athérogène
/
Carence en acide folique
/
Oxidoreductases acting on CH-NH group donors
/
Homocystéine
/
Animaux
/
Souris
/
Souris de lignée C57BL
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
1998
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS