Kinetics and mechanisms of cholesterol esterase inhibition by cardiovascular drugs in vitro.
Indian J Biochem Biophys
;
2006 Feb; 43(1): 52-5
Article
Dans Anglais
| IMSEAR
| ID: sea-27416
ABSTRACT
Cardiovascular drugs such as lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride inhibit cholesterol esterase (CEase) in vitro. In the present paper, an attempt was made to determine kinetically the reaction mechanism for CEase inhibition by these drugs. The inhibition constant, Ki, for the mixed-type inhibition of CEase by these drugs in the presence of triton-X-100 or taurochloate were measured. Moreover, the pKi values were correlated with the molecular weights of these drugs. In conclusion, the fact that these drugs lower cholesterol levels in the plasma low-density lipoprotein may be partially due to the CEase inhibition by these drugs.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Acide taurocholique
/
Cinétique
/
Nifédipine
/
Agents cardiovasculaires
/
Sterol Esterase
/
Amlodipine
/
Octoxinol
/
Simvastatine
/
Antienzymes
/
Hydralazine
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
2006
Type:
Article
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